| Rnd | Team | Match Date | Home Team | Result | Away Team |
|---|
| 1 | Second XI | 1980-10-04 | Spotswood |  | Murrumbeena |
| 7/116 G Hay 2/31 G Burns 3/12 | | 5/129 J McDermott 47 |
| 2 | Second XI | 1980-10-11 | Murrumbeena | lost to | Royal Park |
| 9/104 A Roach 47 | | 6/105 S Goold 4/19 |
| 3 | Second XI | 1980-10-18 | Bentleigh | def | Murrumbeena |
| 8/254 J Crombie 4/88 S Goold 2/49
and 1/13 | | 145 G Burns 46 |
| 5 | Second XI | 1980-11-15 | Murrumbeena | lost to | Brunswick District |
| 134 R Coghill 33 M O'Neill 36* | | 179 G Burns 5/29 S Goold 3/46 J Crombie 2/55
and 1/32 |
| 6 | Second XI | 1980-11-29 | Hampton | def | Murrumbeena |
| 9/153 G Keetley 3/29 J Crombie 3/31 | | 111 S Hay 36
and 14 |
| 7 | Second XI | 1980-12-20 | Murrumbeena | lost to | East Malvern |
| 59 | | 152 A Roach 4/29 |
| 8 | Second XI | 1981-01-17 | South Caulfield | def | Murrumbeena |
| 120 G Hay 2/30 G Burns 7/41 | | 69
and 4/68 PS Newton 27 |
| 9 | First XI | 1981-01-24 | Altona North | def | Murrumbeena |
| 254 A Graham 2/56 P Way 4/28 | | 147 D Hardham 31 |
| 10 | Second XI | 1981-01-26 | Highett | def | Murrumbeena |
| 9/145 A Read 5/25 G Hay 2/30 G Burns 2/20 | | 8/121 S Hay 44* |
| 11 | First XI | 1981-02-14 | Moorabbin Park | def | Murrumbeena |
| 8/177 J Graham 2/36 D Hardham 2/34 P Way 2/36 S Goold 2/28 | | 9/103 P Hay 38 |
| 12 | First XI | 1981-02-21 | Murrumbeena | lost to | Altona North |
| 161 D Hardham 27 A Graham 55
and 107 | | 187 D Hardham 3/20 P Way 6/42 |
