| Rnd | Team | Match Date | Home Team | Result | Away Team |
|---|
| 2 | Second XI | 2021-11-20 | Murrumbeena | lost to | Mentone |
| 191 C Anstee 25 J Lockhart 42 | | 5/232 N Paranagama 2/24 |
| 2 | U17A Sunday | 2021-11-21 | Mazenod OC | def | Murrumbeena |
| 8/112 P Chivers 2/18 S Hawkins 2/25 | | 7/80 C Anstee 27 |
| 1 | Twenty20 XI | 2021-11-23 | Murrumbeena | lost to | Parkdale |
| 9/177 B Kruger 76 | | 4/180 D Parkinson 2/23 |
| 3 | Second XI | 2021-11-27 | Heatherton | def | Murrumbeena |
| 181 Z Goold 2/33 J Anstee 3/13 T Fierenzi 2/26 | | 124 D Venturoni 25 |
| 3 | U17A Sunday | 2021-11-28 | Murrumbeena | lost to | Balwyn |
| 5/124 H Zandberg 53* J Anstee 25 | | 3/158 |
| 4 | Second XI | 2021-12-04 | Murrumbeena | tied | Hampton |
| 9/185 A Frangoulis 51 S Hillemacher 34* J Anstee 34 | | 7/185 P Gupta 2/34 S Hillemacher 2/39 |
| 4 | U17A Sunday | 2021-12-05 | Murrumbeena |  | Mt Waverley |
| 1/164 C Anstee 98* S Hillemacher 44* | | 6/112 J Vanderkruk 2/9 R Murphy 2/15 |
| 2 | Twenty20 XI | 2021-12-07 | St Brigids/St Louis | | Murrumbeena |
| 8/123 D Venturoni 2/18 N Paranagama 2/17 M Guruge 2/20 | | 5/125 B Kruger 27 |
| 5 | Second XI | 2021-12-11 | Murrumbeena | | Mordialloc |
| 1/170 Z Goold 51* J Williams 98* | | 7/166 T Kelly 3/14 |
| 6 | Second XI | 2021-12-18 | McKinnon | | Murrumbeena |
| 170 D Parkinson 3/29 D Venturoni 2/9 S Hillemacher 3/17 P Chivers 2/47 | | 6/207 C Anstee 75 T Kelly 27 |
| 6 | U17A Sunday | 2021-12-19 | Murrumbeena | lost to | Melbourne High School |
| 5/103 C Anstee 40 | | 3/106 S Hillemacher 2/15 |
| 8 | Second XI | 2022-01-15 | Murrumbeena | lost to | Beaumaris |
| 9/189 C Anstee 26 J Walker 60 | | 7/193 Z Goold 2/33 S Hillemacher 2/20 |
| 9 | Second XI | 2022-01-22 | Mentone | def | Murrumbeena |
| 4/141 | | 137 J Bailey 34 J Martin 37 |
| 7 | U17A Sunday | 2022-01-23 | Murrumbeena | | Mazenod OC |
| 7/101 H Zandberg 37 J Anstee 34 | | 85 P Chivers 4/17 F Raistrick 2/7 |
| 10 | Second XI | 2022-01-29 | Murrumbeena | lost to | Heatherton |
| 114 | | 9/276 S Hillemacher 4/49 P Chivers 2/61 N Paranagama 2/45 |
| 8 | U17A Sunday | 2022-01-30 | Murrumbeena | lost to | Oakleigh |
| 118 W Parkin 48* | | 6/122 P Chivers 2/24 F Raistrick 2/11 |
