| Rnd | Team | Match Date | Home Team | Result | Away Team |
|---|
| 2 | Second XI | 2021-11-20 | Murrumbeena | lost to | Mentone |
| 191 C Anstee 25 J Lockhart 42 | | 5/232 N Paranagama 2/24 |
| 2 | U17A Sunday | 2021-11-21 | Mazenod OC | def | Murrumbeena |
| 8/112 P Chivers 2/18 S Hawkins 2/25 | | 7/80 C Anstee 27 |
| 3 | Second XI | 2021-11-27 | Heatherton | def | Murrumbeena |
| 181 Z Goold 2/33 J Anstee 3/13 T Fierenzi 2/26 | | 124 D Venturoni 25 |
| 3 | U17A Sunday | 2021-11-28 | Murrumbeena | lost to | Balwyn |
| 5/124 H Zandberg 53* J Anstee 25 | | 3/158 |
| 4 | Second XI | 2021-12-04 | Murrumbeena | tied | Hampton |
| 9/185 A Frangoulis 51 S Hillemacher 34* J Anstee 34 | | 7/185 P Gupta 2/34 S Hillemacher 2/39 |
| 5 | Third XI | 2021-12-11 | Bentleigh | def | Murrumbeena |
| 3/169 | | 159 H Zandberg 48* I Khan 27 |
| 6 | Second XI | 2021-12-18 | McKinnon |  | Murrumbeena |
| 170 D Parkinson 3/29 D Venturoni 2/9 S Hillemacher 3/17 P Chivers 2/47 | | 6/207 C Anstee 75 T Kelly 27 |
| 6 | U17A Sunday | 2021-12-19 | Murrumbeena | lost to | Melbourne High School |
| 5/103 C Anstee 40 | | 3/106 S Hillemacher 2/15 |
| 8 | Second XI | 2022-01-15 | Murrumbeena | lost to | Beaumaris |
| 9/189 C Anstee 26 J Walker 60 | | 7/193 Z Goold 2/33 S Hillemacher 2/20 |
| 9 | Third XI | 2022-01-22 | Parkdale United | | Murrumbeena |
| 99 O Hillemacher 2/11 P Chivers 2/32 | | 3/187 S Hawkins 64 D Venturoni 66* |
| 7 | U17A Sunday | 2022-01-23 | Murrumbeena | | Mazenod OC |
| 7/101 H Zandberg 37 J Anstee 34 | | 85 P Chivers 4/17 F Raistrick 2/7 |
| 10 | Second XI | 2022-01-29 | Murrumbeena | lost to | Heatherton |
| 114 | | 9/276 S Hillemacher 4/49 P Chivers 2/61 N Paranagama 2/45 |
| 8 | U17A Sunday | 2022-01-30 | Murrumbeena | lost to | Oakleigh |
| 118 W Parkin 48* | | 6/122 P Chivers 2/24 F Raistrick 2/11 |
| 11 | Second XI | 2022-02-05 | Hampton | | Murrumbeena |
| 8/169 D Venturoni 2/18 S Hillemacher 2/36 | | 7/184 A Frangoulis 63 H Zandberg 38 |
| 9 | U17A Sunday | 2022-02-06 | Box Hill | def | Murrumbeena |
| 5/105 P Chivers 2/23 | | 9/102 H Zandberg 52 |
| 10 | U17 Friday | 2022-02-11 | Murrumbeena | | Ashwood |
| 2/136 H Zandberg 55 J Singh 28* | | 7/134 J Singh 2/26 G Nandini 2/8 |
| 12 | Second XI | 2022-02-12 | Mordialloc | def | Murrumbeena |
| 207 J Bailey 2/37 A Frangoulis 3/19 T Fierenzi 4/25 | | 193 J Flynn 71 H Zandberg 63 |
| 13 | Second XI | 2022-02-19 | Murrumbeena | lost to | McKinnon |
| 9/178 J Williams 26 A Frangoulis 52 | | 6/181 S Hillemacher 2/27 N Paranagama 2/38 |
| 11 | U17A Sunday | 2022-02-20 | Melbourne High School | def | Murrumbeena |
| 7/110 J Vanderkruk 3/9 | | 9/76 |
