| Rnd | Team | Match Date | Home Team | Result | Away Team |
|---|
| 2 | Second XI | 2021-11-20 | Murrumbeena | lost to | Mentone |
| 191 C Anstee 25 J Lockhart 42 | | 5/232 N Paranagama 2/24 |
| 3 | Second XI | 2021-11-27 | Heatherton | def | Murrumbeena |
| 181 Z Goold 2/33 J Anstee 3/13 T Fierenzi 2/26 | | 124 D Venturoni 25 |
| 5 | Second XI | 2021-12-11 | Murrumbeena |  | Mordialloc |
| 1/170 Z Goold 51* J Williams 98* | | 7/166 T Kelly 3/14 |
| 6 | Second XI | 2021-12-18 | McKinnon | | Murrumbeena |
| 170 D Parkinson 3/29 D Venturoni 2/9 S Hillemacher 3/17 P Chivers 2/47 | | 6/207 C Anstee 75 T Kelly 27 |
| 8 | Second XI | 2022-01-15 | Murrumbeena | lost to | Beaumaris |
| 9/189 C Anstee 26 J Walker 60 | | 7/193 Z Goold 2/33 S Hillemacher 2/20 |
| 10 | First XI | 2022-01-29 | Carnegie | | Murrumbeena |
| 128 N Karunarathne 5/41 T Kelly 2/26 | | 8/172 D Parkinson 35 X Ross 61* |
| 11 | First XI | 2022-02-05 | Murrumbeena | lost to | Hampton |
| 9/206 X Ross 81* D Parkinson 46 | | 5/216 A Hay 2/12 |
| 12 | First XI | 2022-02-12 | Murrumbeena | | Mordialloc |
| 5/213 AR Ross 122* D Parkinson 43* | | 125 N Karunarathne 4/20 M Guruge 3/19 |
| 13 | First XI | 2022-02-19 | Bentleigh | def | Murrumbeena |
| 1/101 | | 100 W Kelly 27 |
| 14 | First XI | 2022-02-26 | Bonbeach | def | Murrumbeena |
| 3/135 | | 134 A Hay 40 M Guruge 25* |
