| Rnd | Match Date | Home Team | Result | Away Team |
|---|
| 1 | 2021-11-13 | Murrumbeena | no play | Beaumaris |
| 2 | 2021-11-20 | South Caulfield | def | Murrumbeena |
| 4/186 M Guruge 3/19 | | 9/185 B Kruger 59 B Hardham 56 |
| 3 | 2021-11-27 | Murrumbeena | no play | Carnegie |
| 4 | 2021-12-04 | Hampton |  | Murrumbeena |
| 158 D Parkinson 3/40 M Guruge 3/24 | | 7/187 A Hay 39 AR Ross 79 |
| 5 | 2021-12-11 | Mordialloc | def | Murrumbeena |
| 9/141 N Karunarathne 2/19 M Guruge 2/12 N Paranagama 2/48 | | 139 |
| 6 | 2021-12-18 | Murrumbeena | | Bentleigh |
| 9/169 A Hay 29 B Kruger 32 | | 138 T Ryan 4/29 N Paranagama 3/35 |
| 7 | 2022-01-08 | Murrumbeena | no play | Bonbeach |
| 8 | 2022-01-15 | Beaumaris | | Murrumbeena |
| 146 B Kruger 3/24 M Guruge 2/20 T Ryan 2/32 | | 7/147 B Kruger 80 |
| 9 | 2022-01-22 | Murrumbeena | lost to | South Caulfield |
| 207 B Kruger 73 W Kelly 43 | | 4/208 |
| 10 | 2022-01-29 | Carnegie | | Murrumbeena |
| 128 N Karunarathne 5/41 T Kelly 2/26 | | 8/172 D Parkinson 35 X Ross 61* |
| 11 | 2022-02-05 | Murrumbeena | lost to | Hampton |
| 9/206 X Ross 81* D Parkinson 46 | | 5/216 A Hay 2/12 |
| 12 | 2022-02-12 | Murrumbeena | | Mordialloc |
| 5/213 AR Ross 122* D Parkinson 43* | | 125 N Karunarathne 4/20 M Guruge 3/19 |
| 13 | 2022-02-19 | Bentleigh | def | Murrumbeena |
| 1/101 | | 100 W Kelly 27 |
| 14 | 2022-02-26 | Bonbeach | def | Murrumbeena |
| 3/135 | | 134 A Hay 40 M Guruge 25* |
