| Rnd | Match Date | Home Team | Result | Away Team |
|---|
| 1 | 2021-11-13 | Beaumaris | no play | Murrumbeena |
| 2 | 2021-11-20 | Murrumbeena | lost to | Mentone |
| 191 C Anstee 25 J Lockhart 42 | | 5/232 N Paranagama 2/24 |
| 3 | 2021-11-27 | Heatherton | def | Murrumbeena |
| 181 Z Goold 2/33 J Anstee 3/13 T Fierenzi 2/26 | | 124 D Venturoni 25 |
| 4 | 2021-12-04 | Murrumbeena | tied | Hampton |
| 9/185 A Frangoulis 51 S Hillemacher 34* J Anstee 34 | | 7/185 P Gupta 2/34 S Hillemacher 2/39 |
| 5 | 2021-12-11 | Murrumbeena |  | Mordialloc |
| 1/170 Z Goold 51* J Williams 98* | | 7/166 T Kelly 3/14 |
| 6 | 2021-12-18 | McKinnon | | Murrumbeena |
| 170 D Parkinson 3/29 D Venturoni 2/9 S Hillemacher 3/17 P Chivers 2/47 | | 6/207 C Anstee 75 T Kelly 27 |
| 7 | 2022-01-08 | Bonbeach | no play | Murrumbeena |
| 8 | 2022-01-15 | Murrumbeena | lost to | Beaumaris |
| 9/189 C Anstee 26 J Walker 60 | | 7/193 Z Goold 2/33 S Hillemacher 2/20 |
| 9 | 2022-01-22 | Mentone | def | Murrumbeena |
| 4/141 | | 137 J Bailey 34 J Martin 37 |
| 10 | 2022-01-29 | Murrumbeena | lost to | Heatherton |
| 114 | | 9/276 S Hillemacher 4/49 P Chivers 2/61 N Paranagama 2/45 |
| 11 | 2022-02-05 | Hampton | | Murrumbeena |
| 8/169 D Venturoni 2/18 S Hillemacher 2/36 | | 7/184 A Frangoulis 63 H Zandberg 38 |
| 12 | 2022-02-12 | Mordialloc | def | Murrumbeena |
| 207 J Bailey 2/37 A Frangoulis 3/19 T Fierenzi 4/25 | | 193 J Flynn 71 H Zandberg 63 |
| 13 | 2022-02-19 | Murrumbeena | lost to | McKinnon |
| 9/178 J Williams 26 A Frangoulis 52 | | 6/181 S Hillemacher 2/27 N Paranagama 2/38 |
| 14 | 2022-02-26 | Murrumbeena | | Bonbeach |
| 274 J Williams 103 H Zandberg 97 | | 222 J Williams 2/28 S Hawkins 2/30 D Venturoni 3/38 S Hillemacher 2/30 |
