| Rnd | Match Date | Home Team | Result | Away Team |
|---|
| 1 | 2021-11-13 | Murrumbeena | no play | Parkdale |
| 2 | 2021-11-20 | Murrumbeena |  | Parkdale United |
| 7/122 L Hardham 25 I Khan 26 | | 8/119 T Emrose 2/13 I Khan 2/11 |
| 3 | 2021-11-27 | Mordialloc | def | Murrumbeena |
| 4/97 | | 91 P Gupta 26 |
| 4 | 2021-12-04 | Murrumbeena | | Mentone |
| 3/118 L Hardham 38* S Hawkins 37 | | 114 S Hawkins 2/15 T Emrose 2/22 J Ward 2/13 R Parton 2/22 |
| 5 | 2021-12-11 | Bentleigh | def | Murrumbeena |
| 3/169 | | 159 H Zandberg 48* I Khan 27 |
| 6 | 2021-12-18 | Bye | | Murrumbeena |
| 7 | 2022-01-08 | Murrumbeena | no play | St Brigids/St Louis |
| 8 | 2022-01-16 | Parkdale | def | Murrumbeena |
| 5/156 O Hillemacher 3/23 | | 5/155 L Hardham 57 S Hawkins 38 |
| 9 | 2022-01-22 | Parkdale United | | Murrumbeena |
| 99 O Hillemacher 2/11 P Chivers 2/32 | | 3/187 S Hawkins 64 D Venturoni 66* |
| 10 | 2022-01-29 | Murrumbeena | no play | Mordialloc |
| 11 | 2022-02-06 | Mentone | def | Murrumbeena |
| 7/164 P Hay 2/16 I Khan 2/31 O Hillemacher 2/31 | | 8/163 T Emrose 33 I Khan 34 |
| 12 | 2022-02-12 | Murrumbeena | lost to | Bentleigh |
| 6/75 L Hardham 25* | | 8/141 L Anstee 2/10 J Ward 2/16 |
| 13 | 2022-02-19 | Murrumbeena | | Bye |
| 14 | 2022-02-26 | St Brigids/St Louis | def | Murrumbeena |
| 4/128 S Briggs 2/9 | | 5/127 T Emrose 30 M Goold 44 |
