| Rnd | Match Date | Home Team | Result | Away Team |
|---|
| 1 | 2021-11-14 | Box Hill | no play | Murrumbeena |
| 2 | 2021-11-21 | Mazenod OC | def | Murrumbeena |
| 8/112 P Chivers 2/18 S Hawkins 2/25 | | 7/80 C Anstee 27 |
| 3 | 2021-11-28 | Murrumbeena | lost to | Balwyn |
| 5/124 H Zandberg 53* J Anstee 25 | | 3/158 |
| 4 | 2021-12-05 | Murrumbeena |  | Mt Waverley |
| 1/164 C Anstee 98* S Hillemacher 44* | | 6/112 J Vanderkruk 2/9 R Murphy 2/15 |
| 5 | 2021-12-12 | Bye | | Murrumbeena |
| 6 | 2021-12-19 | Murrumbeena | lost to | Melbourne High School |
| 5/103 C Anstee 40 | | 3/106 S Hillemacher 2/15 |
| 7 | 2022-01-23 | Murrumbeena | | Mazenod OC |
| 7/101 H Zandberg 37 J Anstee 34 | | 85 P Chivers 4/17 F Raistrick 2/7 |
| 8 | 2022-01-30 | Murrumbeena | lost to | Oakleigh |
| 118 W Parkin 48* | | 6/122 P Chivers 2/24 F Raistrick 2/11 |
| 9 | 2022-02-06 | Box Hill | def | Murrumbeena |
| 5/105 P Chivers 2/23 | | 9/102 H Zandberg 52 |
| 10 | 2022-02-13 | Murrumbeena | | Bye |
| 11 | 2022-02-20 | Melbourne High School | def | Murrumbeena |
| 7/110 J Vanderkruk 3/9 | | 9/76 |
| 12 | 2022-02-27 | Croydon | | Murrumbeena |
| 7/110 J Vanderkruk 2/11 S Hawkins 3/10 | | 1/144 H Zandberg 59 W Parkin 55* |
| 13 | 2022-03-06 | Murrumbeena | no play | Mt Waverley |
