| Rnd | Match Date | Home Team | Result | Away Team |
|---|
| 1 | 2021-11-13 | Brighton District | no play | Murrumbeena |
| 2 | 2021-11-20 | Bentleigh |  | Murrumbeena |
| 95 H Adapa 3/18 K Inampudi 2/12 T De Rose 3/12(inc hat-trick) | | 124 H Adapa 28 R Singh 30 |
| 3 | 2021-11-27 | Murrumbeena | | Beaumaris |
| 166 R Mathyam 52 R Singh 38 S Thangaraju 30 | | 139 R Mathyam 2/18 J Patel 3/29 K Inampudi 3/13 |
| 4 | 2021-12-04 | Murrumbeena | | Middle Park |
| 9/144 R Mathyam 28 S Thangaraju 49* | | 6/143 J Patel 3/11 |
| 5 | 2021-12-11 | Bayside | | Murrumbeena |
| 89 K Inampudi 4/16 S Adapa 3/13 | | 6/205 R Mathyam 50N R Singh 26* S Thangaraju 35 |
| 6 | 2021-12-18 | Murrumbeena | | McKinnon |
| 6/123 R Mathyam 50N J Patel 25 | | 5/119 J Patel 4/22 |
| 7 | 2022-01-08 | Bonbeach | no play | Murrumbeena |
| 8 | 2022-01-15 | Murrumbeena | | Bentleigh |
| 9/117 S Thangaraju 26 | | 113 J Patel 5/23 K Inampudi 2/18 |
| 9 | 2022-01-22 | Murrumbeena | | Bye |
| 10 | 2022-01-29 | Beaumaris | no play | Murrumbeena |
| 11 | 2022-02-05 | Middle Park | def | Murrumbeena |
| 9/158 J Patel 3/27 K Inampudi 3/33 | | 142 S Erharter 34 J Patel 27 |
| 12 | 2022-02-12 | Murrumbeena | | Bayside |
| 174 V Mehta 43 J Patel 60 | | 9/145 V Mehta 2/24 J Patel 3/31 S Adapa 2/20 |
| 13 | 2022-02-19 | McKinnon | | Murrumbeena |
| 7/82 K Inampudi 2/8 H Adapa 2/7 J Patel 2/16 | | 1/83 K Padmanabhan 31* |
| 14 | 2022-02-26 | Murrumbeena | | Chelsea |
| 4/84 P Gupta 28* | | 82 P Gupta 2/7 H Adapa 2/6 S Adapa 3/12 |
| SF | 2022-03-05 | Murrumbeena | lost to | Middle Park |
| 7/148 K Padmanabhan 50N | | 3/149 J Patel 3/22 |
| PF | 2022-03-12 | Murrumbeena | lost to | Brighton District |
| 82 J Patel 34 | | 7/85 J Patel 2/15 R Singh 2/13 |
